Komen Scholar Spotlight

Susan M. Domchek, M.D., is the Basser Professor of Oncology in the Department of Medicine in Perelman School of Medicine at the University of Pennsylvania School of Medicine (Penn). She is the Executive Director of the Basser Research Center for BRCA at the Abramson Cancer Center and the Director of the MacDonald Cancer Risk Evaluation Program at Penn. A clinician and researcher, Dr. Domchek’s research focuses on the role genes play in the risk of developing breast and ovarian cancer as well as the management of individuals with hereditary cancer. Her research expertise includes breast cancer prevention and screening, and clinical trials examining medications targeting tumors due to inherited gene mutations. Her research group has demonstrated that women with BRCA1 and BRCA2 mutations who undergo oophorectomy (surgical removal of the ovaries) significantly reduce their risk of breast and ovarian cancer and that specific medications (PARP inhibitors) can be effective in BRCA1/2 associated cancers. Dr. Domchek’s Komen funding supports the evaluation of newer genes associated with breast and ovarian cancer and lead to better prevention and treatment options for breast cancer patients.